Five Big Ten players were taken in rounds 21-30 of the 2010 MLB First-Year Player Draft, bringing the total number of conference draft picks to 19 at the conclusion of Day 2.
#667 Kurtis Muller, OF, Iowa - Cincinnati Reds
#758 Ethan Wilson, SS, Indiana - Chicago White Sox
#875 Zach Hurley, RF, Ohio State - Oakland Athletics
#878 Michael Earley, OF, Indiana - Chicago White Sox
#917 Zach Robertson, LHP, Iowa - Florida Marlins