Drew Brees, QB, New Orleans (Purdue) - Recorded 279 passing yards and two touchdowns, completing 24 of 39 passes in New Orleans' 30-20 loss to Arizona.
Ray Edwards, DE, Minnesota (Purdue) - Made seven total tackles along with 1.5 sacks in Minnesota's 29-20 loss to the New York Jets.
Lee Evans, WR, Buffalo (Wisconsin) - Caught five passes for 87 yards and a touchdown in Buffalo's 36-26 loss to Jacksonville.
Charles Godfrey, S, Carolina (Iowa) - Made four tackles and grabbed an interception in Carolina's 23-6 loss to Chicago.
Brandon Graham, DE, Philadelphia (Michigan) - Made two tackles and a fumble-forcing sack in Philadelphia's 27-24 win over San Francisco.
Shonn Greene, RB, New York Jets (Iowa) - Rushed for 57 yards and a touchdown on 10 carries in the New York Jets' 29-20 win over Minnesota.
Tamba Hali, LB, Kansas City (Penn State) - Made six tackles and a sack in Kansas City's 19-9 loss to Indianapolis.
Mike Hart, RB, Indianapolis (Michigan) - Rushed for 50 yards and a touchdown on 11 carries in Indianapolis' 19-9 win over Kansas City.
Aaron Kampman, DE, Jacksonville (Iowa) - Made six total tackles and 1.5 sacks in Jacksonville's 36-26 win over Buffalo.
Brandon Lloyd, WR, Denver (Illinois) - Racked up 135 yards receiving along with two touchdowns on five catches in Denver's 31-17 loss to Baltimore.
Mike Neal, DE, Green Bay (Purdue) - Made two tackles and a sack in Green Bay's 16-13 loss to Washington.
Kyle Orton, QB, Denver (Purdue) - Threw for 314 yards and two touchdowns on 23 of 38 passing in Denver's 31-17 loss to Baltimore.
Julian Peterson, LB, Detroit (Michigan State) - Made 11 tackles and a sack in Detroit's 44-6 win over St. Louis.
Paul Posluszny, LB, Buffalo (Penn State) - Racked up 13 tackles in Buffalo's 36-26 loss to Jacksonville.
Matt Shaughnessy, DE, Oakland (Wisconsin) - Recorded six tackles and a sack in Oakland's 35-27 win over San Diego.
Anthony Spencer, LB, Dallas (Purdue) - Made three tackles and recorded a sack in Dallas' 34-27 loss to Tennessee.