Drew Brees, QB, New Orleans (Purdue) - Completed 31 of 35 passes for 325 yards and five touchdowns in New Orleans' 62-7 win over Indianapolis.
Plaxico Burress, WR, New York Jets (Michigan State) - Caught four passes, three of which resulted in touchdowns, for 25 yards in the New York Jets' 27-21 win over San Diego.
Dan Connor, LB, Carolina (Penn State) - Made 10 tackles in Carolina's 33-20 win over Washington.
Shonn Greene, RB, New York Jets (Iowa) - Ran for 112 yards on 20 carries in the New York Jets' 27-21 win over San Diego.
Chad Greenway, LB, Minnesota (Iowa) - Recorded 11 tackles in Minnesota's 33-27 loss to Green Bay.
DeAndre Levy, LB, Detroit (Wisconsin) - Posted 11 tackles in Detroit's 23-16 loss to Atlanta.
Michael Jenkins, WR, Minnesota (Ohio State) - Racked up 111 yards and a touchdown on three receptions in Minnesota's 33-27 loss to Green Bay.
Shaun Phillips, LB, San Diego (Purdue) - Recorded six tackles and two sacks in San Diego's 27-21 loss to the New York Jets.
Barrett Ruud, LB, Tennessee (Nebraska) - Had 10 tackles in Tennessee's 41-7 loss to Houston.
Eric Smith, S, New York Jets (Michigan State) - Posted 10 tackles in the New York Jets' 27-21 win over San Diego.
Amari Speivey, S, Detroit (Iowa) - Recorded an interception and added six tackles in Detroit's 23-16 loss to Atlanta.
Cameron Wake, LB, Miami (Penn State) - Recorded two sacks and four total tackles in Miami's 18-15 overtime loss to Denver.
LaMarr Woodley, LB, Pittsburgh (Michigan) - Posted seven tackles and two sacks in Pittsburgh's 32-20 win over Arizona.
Charles Woodson, CB, Green Bay (Michigan) - Grabbed two interceptions and made four tackles in Green Bay's 33-27 win over Minnesota.