Tom Brady, QB, New England (Michigan) - Completed 29 of 38 passes for 289 yards and two touchdowns in New England's 31-24 win over Indianapolis.
Drew Brees, QB, New Orleans (Purdue) - Passed for 342 yards and three touchdowns on 26 of 36 passing in New Orleans' 31-17 win over Detroit.
Kurt Coleman, S, Philadelphia (Ohio State) - Posted 11 tackles in Philadelphia's 31-14 loss to Seattle.
Charles Godfrey, S, Carolina (Iowa) - Recorded 11 tackles in Carolina's 38-19 win over Tampa Bay.
Shonn Greene, RB, New York Jets (Iowa) - Scored three touchdowns and rushed for 88 yards on 22 carries in the New York Jets' 34-19 win over Washington.
Roy Helu, RB, Washington (Nebraska) - Rushed for 100 yards and a touchdown on 23 carries and added four catches for 42 yards in Washington's 34-19 loss to the New York Jets.
Santonio Holmes, WR, New York Jets (Ohio State) - Caught four passes for 58 yards and a touchdown in the New York Jets' 34-19 win over Washington.
James Laurinaitis, LB, St. Louis (Ohio State) - Racked up 12 tackles and a sack in St. Louis' 26-0 loss to San Francisco.
Rashard Mendenhall, RB, Pittsburgh (Illinois) - Rushed for 60 yards and two touchdowns on 16 carries in Pittsburgh's 35-7 win over Cincinnati.
Tracy Porter, CB, New Orleans (Indiana) - Made seven tackles and an interception in New Orleans' 31-17 win over Detroit.
Paul Posluszny, LB, Jacksonville (Penn State) - Notched 11 tackles in Jacksonville's 38-14 loss to San Diego.
Amari Spievey, S, Detroit (Iowa) - Recorded 10 tackles in Detroit's 31-17 loss to New Orleans.
Beanie Wells, RB, Arizona (Ohio State) - Rushed for 67 yards and a touchdown on 20 carries in Arizona's 19-13 overtime win over Dallas.