Cliff Avril, LB, Detroit (Purdue) - Took an interception back for a touchdown in Detroit's 38-10 win over San Diego.
NaVorro Bowman, LB, San Francisco (Penn State) - Made 12 tackles, a sack and a tackle for loss in San Francisco's 19-17 win over Seattle.
Tom Brady, QB, New England (Michigan) - Passed for 304 yards and a touchdown on 27 of 46 passing and added two rushing touchdowns in New England's 27-24 win over Miami.
Drew Brees, QB, New Orleans (Purdue) - Became the NFL's all-time single-season passing yards leader after passing for 307 yards and four touchdowns on 23 of 39 passing in New Orleans' 45-16 win over Atlanta.
Nate Clements, CB, Cincinnati (Ohio State) - Grabbed an interception and made four tackles and a tackle for loss in Cincinnati's 23-16 win over Arizona.
Larry Grant, LB, San Francisco (Ohio State) - Recorded 12 tackles and a sack in San Francisco's 19-17 win over Seattle.
Chad Greenway, LB, Minnesota (Iowa) - Notched 16 tackles in Minnesota's 33-26 win over Washington.
David Harris, LB, New York Jets (Michigan) - Made an interception, along with four tackles and a sack, in the New York Jets' 29-14 loss to the New York Giants.
A.J. Hawk, LB, Green Bay (Ohio State) - Made 12 tackles, including one for loss, in Green Bay's 35-21 win over Chicago.
Chris Kelsay, LB, Buffalo (Nebraska) - Recorded 10 tackles, three sacks and two tackles for loss in Buffalo's 40-14 win over Denver.
James Laurinaitis, LB, St. Louis (Ohio State) - Racked up 13 tackles in St. Louis' 27-0 loss to Pittsburgh.
Rashard Mendenhall, RB, Pittsburgh (Illinois) - Rushed for 116 yards and a touchdown on 18 carries in Pittsburgh's 27-0 win over St. Louis.
Rob Ninkovich, LB, New England (Purdue) - Posted six tackles and a sack in New England's 27-24 win over Miami.
Kyle Orton, QB, Kansas City (Purdue) - Threw for 300 yards and a touchdown on 21 of 36 passing in Kansas City's 16-13 overtime loss to Oakland.
Evan Royster, RB, Washington (Penn State) - Recorded 19 carries for 132 yards in Washington's 33-26 loss to Minnesota.
Morgan Trent, CB, Jacksonville (Michigan) - Made four tackles and an interception in Jacksonville's 23-17 loss to Tennessee.
J.J. Watt, DE, Houston (Wisconsin) - Made five tackles, including a sack and two tackles for loss, in Houston's 19-16 loss to Indianapolis.